The software does not "load" , the application will only open up when it detects the Keymander. So for the PC to detect the computer you need at least two cables connected to Keymander in the either of the combinations I gave you above.
The dell keyboard shouldn't be an issue. The mouse we have not tested, for those games I would recommend a mouse with at least 4-5k dpi. But if you have this equipment already I would suggest trying it out.
We have not tested the G203 but we rarely have issues with logitech mice so I do not see why you would have a problem. Now for the keyboard the Redragon M601 Centrophorus did have issues but we do not have any known issues with their keyboards. The model you have we have not tested, I would suggest sticking to something on the compatible list on our first post of this thread.