Every time I click play mode the app closes

Yes it does. And everything is set up. Pc port on keymander to pc and game port to pc

I am having trouble getting this to work.
#1 my ps3 nav controller just blinks.
#2 my keymander software wont open for me to click on the 'play mode' option unless the USB that goes into the xbox is connected to PC as well. Please help!